Alejandro Lopez Hernandez

Post Doc
Postdoctoral researcher

Research Lines

Genomic Science

Center

CGS@SEMM Milano

About

Education

  • 2012 - 2017 International PhD in Biomedicine and Cancer Research at University of Oviedo, Spain.
  • 2011 - 2012 Master in Biomedicine and Molecular Oncology, University of Oviedo, Spain.
  • 2006 - 2011 Bachelor Degree in Biochemistry, University of Oviedo, Spain.

Professional Experience

September 2018- Present            Postdoctoral researcher in the Stefano Campaner's group, Cancer Biology research line, Center for Genomic Science at IIT@SEMM, Milan, Italy.

September 2017- January 2018   Postdoctoral internship at the Department of Head and Neck Oncology (IUOPA), Spain.

December 2012- June 2017         PhD student in the Dr. Hermsen's group, Department of Head and Neck Oncology, The University Institute of Oncology of Asturias (IUOPA), Spain.

            • Thesis: “Sinonasal Cancer: Genetic characterisation and classification of poorly differentiated tumours”.

March- July 2016                          Short-Term PhD Stay in the Dr. Emma Shanks’s group, The Beatson Institute for Cancer Research of Glasgow, United Kingdom.

            • Project: “Strategic evaluation of synergistic drug candidates coupled to inhibition of mTOR for treatment of oral and sinonasal cancers”.

September 2011 – June 2012      Master Thesis in the Dr. Dominguez Luengo’s group, Department of Hormone Receptors and Ion Channels, University of Oviedo, Spain.

            • Project: “Activation of ERK1/2 by TRH and its role in regulation of ERG K + channels”.

Projects

 Characterization novel YAP/TAZ regulators

YAP and TAZ are two transcriptional co-activators that are able to integrate chemical and mechanical signals in order to regulate tissue growth during development, regeneration and cancer. In several cancer types, especially in basal-like breast cancer, TAZ is frequently stabilized and activated but, to date, there is no evidence for recurrent mutations. Moreover, mutations of the physiological upstream regulators, such as the Hippo pathway components, are rare thus suggesting that YAP / TAZ activity in cancer could be controlled through alternative pathways that has undergone oncogenic lesions. This raises the need to identify genes and pathways responsible for the deregulation of YAP and TAZ in cancer cells.

Thus, the aim of this project is to investigate potential regulators of YAP / TAZ transcriptional activity in mammary epithelial cells and establish a comprehensive characterization of the molecular mechanisms that govern the homeostasis of YAP / TAZ in the breast tissue.

Selected Publications

Alejandro López-Hernández, Blanca Vivanco, Alessandro Franchi, et al. Genetic profiling of poorly differentiated sinonasal tumours. Scientific Reports. 2018. Mar 5;8(1):3998.

Alejandro López-Hernández, Jhudit Pérez-Escuredo, Blanca Vivanco, et al. Genomic profiling of intestinal-type sinonasal adenocarcinoma reveals subgroups of patients with distinct clinical outcomes. Head Neck. 2018 Feb;40(2):259-273.

Cristina Riobello, Alejandro López-Hernández, Virginia Naves-Cabal, et al. IDH2 Mutation Analysis in Undifferentiated and Poorly Differentiated Sinonasal Carcinomas for Diagnosis and Clinical Management. Am J Surg Pathol. 2020 Mar;44(3):396-405.

Cristina Riobello, Blanca Vivanco, Sara Reda, Alejandro López-Hernández, et al. Programmed death ligand-1 expression as immunotherapeutic target in sinonasal cancer. Head Neck. 2018 Apr;40(4):818-827.

Esteban Pacheco, José Luis Llorente, Alejandro López-Hernández, et al. Absence of Chromosomal Translocations and Protein Expression of ALK in Sinonasal Adenocarcinomas. Acta Otorrinolaringol Esp. 2017 Jan - Feb;68(1):9-14.

 María Costales, Alejandro López-Hernández, Cristina García-Inclán, et al. Gene Methylation Profiling in Sinonasal Adenocarcinoma and Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2016 Nov;155(5):808-815.

Jhudit Pérez Escuredo, Alejandro López Hernández, María Costales, et al. Recurrent DNA copy number alterations in intestinal-type sinonasal adenocarcinoma. Rhinology. 2016 Sep;54(3):278-86.

Cristina García Inclán, Alejandro López Hernández, Marta Alonso Guervos, et al. Establishment and genetic characterization of six unique tumour cell lines as preclinical models for sinonasal squamous cell carcinoma. Scientific Reports. 4 -4925, 12/05/2014.

Luis Carretero, Pablo Llavona, Alejandro López Hernández, et al. ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Cellular Signaling. 27-9, pp. 1720 - 1730. Elsevier, 25/05/2015.